My main research foci are RNA consensus structure prediction and
benchmarking of RNA alignment programs.
I'm maintaining
ConStruct
(we released version 3 - no new publication though). ConStruct combines thermodynamic structure prediction and mutual
information statistics in a semiautomatic tool for RNA consensus
structure prediction. Its sophisticated GUI allows for an easy alignment correction and its
built-in structure prediction routines can predict optimal and
suboptimal consensus structures as well as tertiary
interactions. See
ConStruct's homepage and
Presentations below for more
information.
Find the
old homepage here.
My Ph.D. thesis was also concerned with RNA alignment benchmarking.
In collaboration with
Stefan Washietl
and
Paul Gardner
we carried out and published the
first RNA alignment benchmark conducted so far
(BRAliBase II; see Paul
Gardner's BRAliBase webpage).
A sequel to this
benchmark, which includes test-sets with varying number
of sequences, parameter optimization of alignment programs and
statistical analysis followed in 2006 (see BRAliBase 2.1 webpage).