Research topics

Development of bioinformatic tools Thermodynamic stability of double-stranded nucleic acids. Thermodynamic Prediction of Conserved Secondary Structure in RNA. Thermodynamic stability of single-stranded nucleic acids. Kinetic/sequential folding of single-stranded nucleic acids. Search for and description of hybrid patterns. (see DFG-Schwerpunkt Bioinformatik) Biophysics/Bioinformatics Thermodynamics and kinetics of nucleic acids Methods Temperature-gradient gel-electrophoresis (TGGE) Optical denaturation curves Hydrodynamics T-jump Objects Viroids Viral RNAs Ribozymes (Of course, our tools are independent from the type of nucleic acid.)

Services BiophysWWW supplies

Poland: Prediction of melting transitions of dsRNA, DNA or RNA/DNA hybrids.   Tinoco Plot: Display possible secondary structure elements in single stranded RNA or DNA.   Dot Plot: Display possible intermolecular secondary structure elements between two single stranded RNA or DNA molecules.   Langmuir: Evaluate binding curves (adsorption isotherms) according to Hill or Langmuir.   ConStruct v2.0: Download source code for ``ConStruction of RNA Consensus Structures''.   StrAl: Multiple alignment of non-coding RNAs.